Polio Research Today is a free monthly online journal that collates and summarizes the latest research about Polio, including details on symptoms, treatment, vaccines, causes, virus.

Treatment for postpolio syndrome.

Koopman FS, Uegaki K, Gilhus NE, Beelen A, de Visser M, Nollet F

Department of Rehabilitation, University of Amsterdam Academic Medical Center, PO Box 22660, Amsterdam, North Holland, Netherlands, 1100 DD.

Published 17 February 2011 in Cochrane Database Syst Rev, 2: CD007818.
Full-text of this article is available online (may require subscription).

Articles on Polio published 7 February 2011:

Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity.   J Virol, 85(5): 2364-72.

Enviroxime is an antienterovirus compound that targets viral protein 3A and/or 3AB and suppresses a step in enterovirus replication by unknown mechanism. To date, four antienterovirus compounds, i.e., GW5074, Flt3 inhibitor II, TTP-8307, and AN-12-H5, are known to have similar mutations in the 3A protein-encoding region causing resistance to enviroxime (a G5318A [3A-Ala70Thr] mutation in poliovirus [PV]) and are considered enviroxime-like compounds. Recently, antienterovirus activity of a ... [Abstract] [Full-text]

Articles on Polio published 21 December 2010:

Post polio syndrome: fatigued patients a specific subgroup?   J Rehabil Med, 43(1): 39-45.

[Abstract] [Full-text]

Post polio syndrome: fatigued patients a specific subgroup?   J Rehabil Med, 43(1): 39-45.

[Abstract] [Full-text]

Articles on Polio published 25 November 2010:

From emergence to eradication: the epidemiology of poliomyelitis deconstructed.   Am J Epidemiol, 172(11): 1213-29.

Poliomyelitis has appeared in epidemic form, become endemic on a global scale, and been reduced to near-elimination, all within the span of documented medical history. Epidemics of the disease appeared in the late 19th century in many European countries and North America, following which polio became a global disease with annual epidemics. During the period of its epidemicity, 1900-1950, the age distribution of poliomyelitis cases increased gradually. Beginning in 1955, the creation of ... [Abstract] [Full-text]

From emergence to eradication: the epidemiology of poliomyelitis deconstructed.   Am J Epidemiol, 172(11): 1213-29.

Poliomyelitis has appeared in epidemic form, become endemic on a global scale, and been reduced to near-elimination, all within the span of documented medical history. Epidemics of the disease appeared in the late 19th century in many European countries and North America, following which polio became a global disease with annual epidemics. During the period of its epidemicity, 1900-1950, the age distribution of poliomyelitis cases increased gradually. Beginning in 1955, the creation of ... [Abstract] [Full-text]

Articles on Polio published 18 November 2010:

Type 2 vaccine-derived poliovirus from patients with acute flaccid paralysis in china: current immunization strategy effectively prevented its sustained transmission.   J Infect Dis, 202(12): 1780-8.

In China, 5 patients with acute flaccid paralysis (AFP) associated with type 2 vaccine-derived poliovirus (VDPV) were identified by an AFP surveillance system from 1996 through 2009. A maximum-likelihood tree shows that all 5 Chinese VDPVs were independent. These 5 VDPVs were 100-216 d old according to the number of synonymous substitutions per synonymous site and 176-292 d old according to the number of substitutions per site. This result indicates limited virus replication since the ... [Abstract] [Full-text]

Type 2 vaccine-derived poliovirus from patients with acute flaccid paralysis in china: current immunization strategy effectively prevented its sustained transmission.   J Infect Dis, 202(12): 1780-8.

In China, 5 patients with acute flaccid paralysis (AFP) associated with type 2 vaccine-derived poliovirus (VDPV) were identified by an AFP surveillance system from 1996 through 2009. A maximum-likelihood tree shows that all 5 Chinese VDPVs were independent. These 5 VDPVs were 100-216 d old according to the number of synonymous substitutions per synonymous site and 176-292 d old according to the number of substitutions per site. This result indicates limited virus replication since the ... [Abstract] [Full-text]

Type 2 vaccine-derived poliovirus from patients with acute flaccid paralysis in china: current immunization strategy effectively prevented its sustained transmission.   J Infect Dis, 202(12): 1780-8.

In China, 5 patients with acute flaccid paralysis (AFP) associated with type 2 vaccine-derived poliovirus (VDPV) were identified by an AFP surveillance system from 1996 through 2009. A maximum-likelihood tree shows that all 5 Chinese VDPVs were independent. These 5 VDPVs were 100-216 d old according to the number of synonymous substitutions per synonymous site and 176-292 d old according to the number of substitutions per site. This result indicates limited virus replication since the ... [Abstract] [Full-text]

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